Recently, scientists have uncovered that after long-term abstinence from alcohol and other drugs, the brain's physiology can start to normalize. By keeping dopamine levels in the brain low, dopamine receptors can begin to return to their higher and natural levels. Agonists and antagonists can be used in the treatment of drug and alcohol addiction. Studies have found that it is not easy to adjust dopamine levels after extensive use of drugs high in dopamine. So how long does it take for dopamine receptors to heal? On average, it can take around 14 months to reach normal levels in the brain with proper treatment and rehabilitation.
There are several factors that influence the intensity of withdrawals associated with the release of dopamine that come from alcohol and other drugs. These factors may differ from person to person, but generally involve the time it takes for dopamine levels to restore to their normal and natural levels. It usually takes about 90 days for people to notice a difference in pleasure experiences and dopamine levels.